Amyloidosis is characterized by tissue deposits of amyloidogenic protein aggregates and fibrils throughout the body, including the heart, skin, liver and spleen. For most of these proteins, such as transthyretin, apoAII, primary antibody light chain, no definitive cure has yet been developed. We believe targeted protein degradation of amyloidogenic aggregates can counteract the pathological tissue deposits essential to amyloidosis.
 Giampaolo Merlini et. al. Amyloidosis: P3athogenesis and New Therapeutic Options. J Clin Oncol.