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AUTOTAC is an innovative drug platforms based on targeted protein degradation using autophagy in the human body. AUTOTAC is an acronym, and stands for Autophagy-Targeting Chimera. AUTOTACs are chimeric ligands, consisting of Target-Binding Ligands and Autophagy-Targeting Ligands, which allow simultaneous recognition of both the protein-of-interest and p62, an autophagy receptor. p62 naturally attaches itself to proteins called LC3, which are found along the inner membrane of delivery vesicles called autophagosomes. Once fully matured, autophagosomes fuse with lysosomes whose highly acidic environment degrades proteins.