Alzheimer's disease is the leading cause of dementia and one of the most common neurodegenerative diseases without a cure. The normally microtubule-associated protein misfolds and accumulates within neurons as pathological aggregates, inducing neurotoxicity. These pathological aggregates can occupy the extracellular space and ‘infect’ other healthy neurons, resulting in progressive neuronal death and brain degeneration. AUTOTACs selectively sequester these tau aggregates and target them to the lysosome for autophagic degradation. We believe that the elimination of these disease-causing aggregates will provide a fundamental and novel cure for Alzheimer's disease.
 M. Paul Murphy et al. Alzheimer’s Disease and the β-Amyloid Peptide. J Alzheimers Dis.
 Changhoon Ji et al. (In revision). Targeted protein degradation via the autophagy-lysosome system: AUTOTAC (autophagy-targeting chimera). Nature Communications
Sources : Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect. Front. Physiol.