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’13 METHOD FOR REGULATING P62 ZZ DOMAIN-MEDIATED AUTOPHAGY AND USE THEREOF (KR, WO)
Date
2021-06-08
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240

’13 METHOD FOR REGULATING P62 ZZ DOMAIN-MEDIATED AUTOPHAGY AND USE THEREOF (KR, WO)

  

The present invention relates to: a method for regulating autophagy comprising a step of making cells come into contact with p62 protein,

the ZZ domain of the p62 protein, or an N-end rule ligand interacting with residues 128-163 in the ZZ domain; and a use thereof.

A protein removal through an N-end rule pathway by using p62, according to the present invention,

can be useful for the development of a therapeutic agent for treating or preventing various diseases caused by the abnormal accumulation of misfolded proteins.