’13 METHOD FOR REGULATING P62 ZZ DOMAIN-MEDIATED AUTOPHAGY AND USE THEREOF (KR, WO)
The present invention relates to: a method for regulating autophagy comprising a step of making cells come into contact with p62 protein,
the ZZ domain of the p62 protein, or an N-end rule ligand interacting with residues 128-163 in the ZZ domain; and a use thereof.
A protein removal through an N-end rule pathway by using p62, according to the present invention,
can be useful for the development of a therapeutic agent for treating or preventing various diseases caused by the abnormal accumulation of misfolded proteins.